zinc finger | zinc finger motif function

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zinc finger*******A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn ) which stabilizes the fold. It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor . See moreZinc fingers were first identified in a study of transcription in the African clawed frog, Xenopus laevis in the laboratory of Aaron Klug. A study of the transcription of a particular RNA sequence revealed that the binding strength of . See moreZinc finger (Znf) domains are relatively small protein motifs that contain multiple finger-like protrusions that make tandem contacts with their . See morezinc finger motif functionVarious protein engineering techniques can be used to alter the DNA-binding specificity of zinc fingers and tandem repeats of such . See more• Biology portal• Technology portal• B-box zinc finger• DNA-binding protein• See moreInitially, the term zinc finger was used solely to describe DNA-binding motif found in Xenopus laevis; however, it is now used to refer to any . See moreThis entry represents the CysCysHisCys (C2HC) type zinc finger domain found in eukaryotes. Proteins containing these domains include:• MYST family histone acetyltransferases• Myelin transcription factor Myt1 See more• C2H2 family Archived 2016-02-15 at the Wayback Machine at PlantTFDB: Plant Transcription Factor Database Archived 2016-04-22 at the Wayback Machine• See more

Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger .

Zinc finger proteins are basically thought of as transcription factors meant primarily to bind DNA. However, some of the zinc finger proteins and related zinc .

Zinc finger proteins are transcription factors with the finger domain, which plays a significant role in gene regulation. As the largest family of transcription factors in .

Zinc finger is a protein structure that binds to DNA or RNA using zinc as a cofactor. Learn about the evolution, function, and applications of zinc finger proteins in various .Learn about the different types of zinc fingers, their functions and how they are annotated in UniProtKB. Zinc fingers are small domains that coordinate zinc ions and are .

Zinc finger (ZF) domains, that represent the majority of the DNA-binding motifs in eukaryotes, are involved in several processes ranging from RNA packaging to .Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, . Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger .

Zinc finger proteins are transcription factors with diverse DNA binding motifs and domains that regulate gene expression in various biological .

The zinc finger was first recognized 15 years ago as a repeated zinc-binding motif, containing conserved cysteine and histidine ligands, in Xenopus transcription factor IIIA (TFIIIA) 1. Since that time, numerous other zinc-binding motifs have been identified and designated as zinc fingers. These vary widely in structure, as well as in function . a ZFD (zinc finger deaminase) architecture. Split-DddA tox halves are fused to the C terminus of ZFPs (zinc finger proteins) (C type). b Optimization of the ZFD platform using pTarget libraries .

Zinc finger proteins (ZNF) can form transcription initiation complexes that bind to DNA-specific regions and mediate transcription. ZNF mainly rely on Zn 2+ to form a stable structure similar to “finger” ( Berg and Shi, 1996 ). Zn 2+ binds with different amounts of Cys and His to form different types of ZNF. ZNF are classified in two . Zinc finger proteins are basically thought of as transcription factors meant primarily to bind DNA. However, some of the zinc finger proteins and related zinc binding motifs are also known to bind to RNA , lipids and some of the other proteins . These proteins serve diverse biological functions in human body, such as in development and . Zinc finger design is facilitated with a deep-learning model. Cys2His2 zinc finger (ZF) domains engineered to bind specific target sequences in the genome provide an effective strategy for . Background Zinc finger proteins encompass one of the unique and large families of proteins with diversified biological functions in the human body. These proteins are primarily considered to be DNA binding transcription factors; however, owing to the diverse array of zinc-finger domains, they are able to interact with molecules other than .Zinc Finger Folds and Functions, Table 1 Fold classes of zinc finger. Full size table. A large proportion of ZnFs use pairs of short bidentate zinc-coordinating motifs (e.g., C-X 2–4 -C) separated by intervening sequences or loops, the sequences and structures of which vary according to the class of ZnF. These motifs usually take the form of . ZINC FINGER PROTEINS – STRUCTURE AND DNA RECOGNITION. The C2H2 ZF domain is the most common type of ZF and is one of the most abundantly expressed proteins in eukaryotic cells. ZFs are small, functional and independently folded domains coordinated with zinc molecules in their structure. The C2H2 ZF folds into a .The complex at upper left (PDB entry 1y0j ) shows zinc fingers from two longer proteins, GATA-1 (which contains two zinc fingers) and FOG-1 (which contains 9 zinc fingers). The specific interaction between these two zinc fingers plays an essential role in the development of blood cells. The HIV-1 nucleocapsid protein shown at lower left (PDB . Zinc finger proteins are abundant in the human proteome and are responsible for a variety of functions. The domains that constitute zinc finger proteins are compact spherical structures, each comprising approximately 30 amino acid residues, but they also have precise molecular factor functions: zinc binding and DNA recognition.The zinc finger protein is a sequence-specific double-stranded DNA (dsDNA)-binding protein (Klug and Schwabe, 1995; Wolfe et al., 2000 ). A zinc finger domain is a small protein structural motif that features zinc ion (Zn 2+ )-mediated structural stabilization. The Cys 2 -His 2 zinc finger domain, which chelates the zinc ion with two cysteine .zinc finger zinc finger motif functionThis approach has been used to make zinc finger nucleases (ZFNs) consisting of four, five or six zinc fingers for a range of applications (note that a five-finger ZFN is constructed using one one-finger and two two-finger units). Studies that have used this method are identified by ‘two-finger modules’ in TABLE 1. Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It contains several zinc finger domains that can selectively bind to certain DNA or RNA and associate with proteins, therefore, ZNF can regulate gene expression at the transcriptional and translational levels. In terms of neurological . Abstract. Zinc fingers are small protein domains in which zinc plays a structural role contributing to the stability of the domain. Zinc fingers are structurally diverse and are present among proteins that perform a broad range of functions in various cellular processes, such as replication and repair, transcription and translation, metabolism and .The coordinating amino acid residues and zinc ions (green) are highlighted. A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) which stabilizes the fold. As the largest family of transcription factors in the human genome, zinc finger (ZNF) proteins are characterized by their different DNA binding motifs, such as C2H2 and Gag knuckle. Different kinds of zinc finger motifs exhibit a wide variety of .

zinc finger Zinc-finger proteins (ZNFs) are one of the most abundant groups of proteins and have a wide range of molecular functions. Given the wide variety of zinc-finger domains, ZNFs are able to interact with DNA, RNA, .

CCCH zinc finger proteins as the name suggests consist of three cysteines and a histidine residue with one or more characteristic CCCH zinc finger domain. The functional importance of these Zinc finger proteins . Zinc finger (ZF) domains, that represent the majority of the DNA-binding motifs in eukaryotes, are involved in several processes ranging from RNA packaging to transcriptional activation, regulation of apoptosis, protein .The term ‘zinc finger’ refers to a group of proteins that have structural features folded around a central Zn2+ that binds to cysteine and histidine polypeptide residues, resulting in a finger-like domain that interdigitates into the major groove of .A zinc finger is a small, functional, independently folded domain that coordinates one or more zinc ions to stabilize its structure through cysteine and/or histidine residues. Zinc fingers are structurally diverse and exhibit a wide range of functions, from DNA- or RNA-binding to protein-protein interactions and membrane association.Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein .

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zinc finger|zinc finger motif function